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Pregnancy Bliss | Reproductive Health Hub

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Nalidixic acid, Nifedipine and Tramadol use in pregnancy

Question: How safe is the use of nalidixic acid tabs,nifedipine tabs and tramadol caps in pregnancy? M.L.A. (Nigeria)


Answer: Nalidixic acid use in pregnancy is not recommended. This antibiotic, used mainly for urinary tract infection, has been shown to cause problems with bone development in animals and in high doses, there is evidence that it could be teratogenic (cause developmental anomalies).  Use in late pregnancy has also been associated with development of a condition called ‘pyloric stenosis’ (narrowing of the stomach outlet) in infancy. Use of Nalidixic acid in pregnancy should be avoided and this recommendation extends to the period of breast-feeding.


Nifedipine can and is often used in pregnancy to treat essential hypertension or pre-eclampsia. It is also occasionally used as a tocolytic, that is; as an agent for reducing the intensity of contractions in threatened pre-term labour. Extensive observational studies over the years indicate that it is safe.


Tramadol is a pain-killer in the mould of Codeine. There is a risk of physical dependence developing if used over a prolonged period of time. For this reason, use in pregnancy is not recommended. When strong short-term pain relief is required, other opiate analgesics (pain-killers) are more effective.



Effect of ultrasound on the baby’s brain

Question: Hi, i just heard a few days ago that ultrasound scan in whole pregnancy may affect the brain tissue of the baby. Is that true?? S.B. (Sudan)


Answer: Ultrasound scanning in pregnancy is a long established test and its safety is not in doubt. From time to time, some ill-founded claims have appeared questioning its safety but there has never been any evidence to show that it can cause harm to the baby.



Significance of placental calcifications on ultrasound

Question: Thank you so much for your quick and helpful response to my previous question..... which encouraged me to ask you another question if you would allow  me to do... I am now 38 weeks pregnant and went to my gynaecologist for routine check up by ultrasound. She found a small few foci of calcifications on the outer border of the placenta. I'm concerned about them is there any possibility that they may affect the baby. Do i have to follow up them are those calcification going to increase? Please for your kind opinion and reply to my question. N.B. (India)


Answer: The so-called placental 'calcifications' are fairly common in late pregnancy. What they actually represent is a deposits of the mineral calcium within the mass of the placenta. In virtually all cases they are not at all significant. If your scan is showing normal fetal growth and amniotic fluid volume, the finding of calcifications in the placenta should not be a concern.



Chicken Pox in early pregnancy

Question: My wife is infected by chicken pox during pregnancy at early stage.(6th week of pregnancy). What will be effect on mother and baby, how does the fetus affect this, and what are the measures to be taken? Please advise. R. (United Arab Emirates)


Answer: 90% of babies whose mothers acquire chicken pox during their pregnancy will escape without any ill-effect. This means, 1 in 10 of the babies will be affected in some way. The effects are varied both in type and severity. They are detailed here.


Once a pregnant woman acquires the infection, there is nothing that can be done to influence the infection or its effect. At six weeks, the main immediate concern is the potential to provoke a miscarriage. It is therefore important that your wife is kept comfortable and pain-free.


Abdominal cramps in very early pregnancy

Question: I am 5 weeks pregnant, I am experiencing abdominal cramps a lot of the time, but have no bleeding. I had a scan at 4 and a half weeks to eliminate the chance of an ectopic pregnancy, and they saw the sac in the uterus, but no heart beat. I have to go back at 6 weeks to check on heartbeat. How worried should I be that I have this pain? It was really bad for a week after my period was due, but is a lot better now, but still there. A.R. (UK)


Answer: Congratulations on your pregnancy. It is, for obvious reasons, impossible for me to be absolutely certain about the cause of those pains you are experiencing. However, it appears unlikely that they have anything to do with the pregnancy. The duration of the symptoms is too long and the absence of vaginal bleeding point away from a possible diagnosis of threatened miscarriage.

The absence of a fetal heart pulsation at under 5 weeks is to be expected. I would agree with your doctors' plan of getting a repeat scan at 6 weeks, at which the fetal heart activity should be visible.



Yoga, meditation and conception

Question: My question is, i had miscarriage in the month of **/**** now i want to conceive again. Should i stop my yoga and meditation before  planning for child? After first miscarrage how many months a person should wait before trying again? G.K. (India)


Answer: I am sorry to hear about your pregnancy loss. There is no problem with continuing with yoga or meditation while trying to conceive. Those activities do not have any negative effect on that quest. As for when you can start trying; this depends on how you feel. Once your periods resume, your body is ready for another pregnancy. As long as you feel psychologically ready, you can start trying
















More questions and answers on the next page

Pre-conception yoga is OK

Want to do yoga and meditation pre-conception? Perfectly good idea!